Just because you don't know how doesn't mean it can't be done.
To size brass to a cartridge that has never existed, there are special case forming dies made. Want a 22 caliber cartridge? There is a die that will form a 22 cal neck on any cartridge case. Want a 40 degree shoulder? There is a die for that as well. Want a straight case wall? Ditto. Tapered case wall? different die. Smaller head size? Base stripping dies will do that. And what's more, these die sets are made and sold by the same die makers that make your run-of-the-mill 243 or 30-06 dies.
Once you have a case or a drawing of a case, a machinist can make a reamer, and then you can cut a chamber in the barrel of your choice. Send a case or drawing of a case to any of the big-name reloading die companies, and they will make you reloading dies, forming dies, trim dies, etc.
All in all, it's not very hard to be a wildcatter, you just have to have imagination, creativity, and an inquisitive nature.