Like KyJim, I'm pretty much satisfied after a box of 50, to include my carry loads..... we're talking revolvers here, not bottom feeders!!
But I also get used to speed loader use with the new gun. I have found some that were, if not incompatible, at least contrary. Sometimes it's just a burr on the cylinder mouths, or the cylinder release needs working in, but I have found grips that interfered with the loader...something you'd need to know if you carry a reload.
Beyond that, I give it a good cleaning, then try it with my LSWC practice loads and see if it's going to be a "leader" at forcing cone, or down near the muzzle. A note on this latter: in over 50 years of handgun use, I've yet to own a Smith that continued to lead up after a suitable break-in period with jacketed rounds. A box or two has been all it's ever taken.
If it's role is a carry piece, I strap it on and use only it on my daily chores here on the farm for a month or two...getting used to it...wearing in the trigger, and fiddling with holster position and rechecking the sights. By carrying it daily, and solely, I'm building muscle memory with the gun and its scabard.
HTH's Rod