Of the handguns I own, I can't say which is most reliable. They all are. I've owned some dogs, but they were quickly discarded.
Dogs I found unreliable and discarded:
Sig Mosquito -- FTF, FTE,
Walther P22 -- FTF, jamming
Colt Delta 10mm -- FTF, broken extractor first time out.
Colt Python -- fall out of time, fail to lock up.
Charter Bulldog .44 -- light primer strikes,
Kimber Super Carry -- FTF, FTE.
These were guns I purchased new. With the exception of the Mosquito, all took trips back to the factory and the problem was resolved and/or the unit was repurchased or traded for something else either at the dealer or by the mfg.