Ruger has a much better feel for what will actually sell than any other manufacturer. They are the ONLY American gun manufacturer that is on solid ground financially. I doubt they made a mistake with either the 327 or 480. Both are niche rounds and I'd say at least 95% of those wanting one already have one.
Ruger doesn't make many mistakes. If they could sell enough to be profitable they would make them. But the market just isn't that strong with either chambering and that isn't likely to change. They aren't going to make the financial mistake of small runs of unprofitable guns just to keep a handful of customers happy.
jmr40, you are forgetting that demand, or "those wanting one", is flexible and dynamic. That's why companies advertise and innovate. The firearms market might be different but the concept isn't.
This thread started with a discussion of how Ruger biffed the marketing and we've had similar discussions in the .327 Club Thread. That marketing involves both who the advertising targets and how, and what specific models are being released for those target groups. This is complicated by the fact that it's a new cartridge
and new guns, and coordinating those things is paramount.
Adopting a new caliber requires an investment on the part of consumers. While deciding to make that investment, many people--especially those who have seen novel cartridges come and go in the past--are going to consider market support and longevity. Having a variety of guns out or on the known horizon, covering different interests for different kinds of shooters, and having ammo on local shelves,
all on day one, goes a long way in forging reputation. If that isn't the case, it multiplies the naysayers and can make consumers, shops, and other manufacturers squeamish in their own investments.
The bottom line is that if you're going to bring a new cartridge to an already saturated market and you really want it to be successful, go big or go home.