I used to be all gung-ho for big bore revolvers. I do like 44 Special. However, I find myself moving toward 38 Special and 357 Magnum. I like the S&W N-Frames and would probably go with a 327 TRR8--but the 5" barrel can be difficult to deal with.
I tried a 325 Thunder Ranch in 45 ACP, but I hated its recoil pattern. I much preferred the heavier 625.
I have not been impressed with recent S&W examples in local gun stores. In the end, I'd just choose the Ruger GP100. It is easy to work on, lacks S&W badly designed and placed LOCK. My particular example has a great trigger. The sights are easily changed and there are quite a few stock options.