I have had really good luck with the longer shots out of my Ruger .357 with a Burris red dot on it, however I think my 625 .45acp will out shoot it at 100 yards.
Despite this being an old post, accurate 100 yard shooting with a handgun isn't about the calibre. It's about the shooter.
A .25 ACP ball round will go right through a 2 x 4 at 100. Won't if you can't hit it.