I'm not answering what is the best, but I can tell you what I've chosen and why.
S&W Model 469... and mine's a very early one, A845xxx serial range, likely 1983 or early 1984.
-WHY- did I pick this? It's my secondary carry. Not my back-up, as I don't carry a BUG. It's the gun that I use for carry when I go to places where carry is prohibited or impossible. Therefore, it is my "primary" carry when my day takes me to places where the gun is forced to be left in the car. So we're talking about school functions with the kids, concerts, sporting events, etc.
If it gets stolen, I'm not out my primary and it didn't cost a heap.
I chose this pistol because I have decades of hands-on experience with S&W 1-2-3rd Gen pistols so the familiarity is absolutely natural for me. I also chose this pistol because it was very low money in a Gunbroker grab.
12+1, alloy frame, DA/SA. Including shipping and my FFL fee, I put this in to my hands for $275, although admittedly, that was more than 7 years ago. The 469 (along with the 669) were the first 2nd Gens that S&W marketed. This pistol is very, very similar to the 6904/6906 series.
It's been a terrific, accurate pistol that has given me zero grief of any manner.