Wear out a gun ...not likely ..../ especially if its well made.
I have a nice 1911 ( wilson combat ) that recently went over 40,000 rds ( its 6 yrs old - bought it new in Fall of 2006 / broke the extractor a few weeks ago - it was shipped to Wilson for repair under warranty - had it back inside of 2 weeks...../ worn out, no ---just needed a new extractor ( and springs once in a while )...
Wilson Combat reports ...they have some barrels, in their "range" guns ...that have well over 750,000 rds thru them with no discernable accuracy deterioration..../ so even though I shoot a lot ....to get one gun, over 750,000 rds ...no, not in my lifetime.
I have some favorite S&W revolvers...model 27's especially that are over 30 yrs old ...and while I don't shoot them every week ...I shoot them quite a bit ...at least 3,000 - 5,000 rds a year..../ and none of them are showing any signs of wearing out yet...