I bought one of the early P22s (target model) as my first handgun, and while I liked the feel of it, stripping and reassembling was the biggest headache of any gun I've owned since then. From that point forward, it would start shedding parts while shooting at the range; I ended up ordering a replacement screw kit because they would vibrate out over the course of a few dozen rounds. (Yes, in retrospect, I should have used Loctite, but it was my first gun.)
It also was quite picky about ammo. I traded it towards a Beretta 9mm and never looked back. By comparison, I currently own a Ruger SR22, and although mine has been a little touchy about ammo, it is still comparatively problem-free.