I carry what I can hit with. Normally, it is my 1911 or my DW 357 with the 4 inch barrell.
I did see a 22 revolver the other day. what impressed me was it had a spare cylinder in 22mag. I am going to take some time to consider it.
When fishing I carry a 45lc/410 single shot derringer. Loaded with #8 shot it will take out a snake with out damaging the bottom of an alluminum boat.