This is what makes a practical rifle:
0) Define the mission.
1) Use the tool that allows you to fulfill the mission's requirements.
Examples:
0) Mission= squirrel hunting
Requirements: max range of engagement=75 yards, small-caliber weapon
Expected firing position: prone
Area of operation: back yard
Concealment: required (so the neighbors can't report you to the cops)
Suppression: advisable (you're within city limits after all)
Now, a lot of you would probably think, "Hey, I can finally use my .50 Barrett", and I can understand that, but when you break it down and ask yourself the tough questions, you realized that a CZ-452 with a 4x scope, using .22 sub-sonic ammo will probably suffice, thus making the CZ-452 the more practical rifle for the mission.