Or more broadly what’s the nastiest recoil in any handgun?
"Nastiest" and heaviest aren't automatically the same thing. While I haven't shot the .50 (I hear its a whole 'nother level) if you can manage the oversize grip of the Desert Eagle (and the effort needed to hold it up
) the .357 and .44 Mags are pussycats for recoil.
General rule, the lighter the gun, the more it kicks. Grip size, shape, construction, and fit in your hand are major factors. Then add in the power of the load fired.
Your style / manner of grip, and your overall skill and experience level play a part as well.
If you're shooting an SA revolver and the hammer bites your thumb, YOU are doing something wrong.
Nastiest, as in most painful, pistol I've shot was actually a 9mm Mauser Broomhandle Bolo. Bigger and heavier than nearly all other 9mm pistols, but the size, and shape of the grip, and particularly the metal slot down the back made it actually painful to shoot.
S&W M29 6.5" with standard factory target grips = painful to shoot with full house loads. Put on Pachmayr's and not so bad.
S&W M29 3" round butt with pachmayr grips =painful to shoot with full house loads, plus the gun lays over on its side from torque.
T/C Contender is .45-70 = stout but not painful, FOR ME. Friend of mine tried it, after watching me shoot it, and smacked himself in the nose!
Bled a bit too!
.357 in a light weight snub nose? NO THANK YOU!!