Biggest is not always, and in fact very rarely the best.
I can make the argument that a 327 federal might be the best all around or maybe even a 32-20 if you weigh each task out evenly, and try to remove the bluster.
I have a 32.20 single six. with that very easy to carry gun i can shoot 100 JHP at close to 1100 FPS, fast enough to make you say enough, I can shoot 100 hard cast wadcutters, 85 grain wadcutters, and single round ball 00 buck loads from 550 FPS to about 1200 FPS.
Too light for self defense? its the near equal to many many 9mm loads, so its in the range, maybe not perfect but darn close. Hunting? I have killed deer with it. Killed pheasant, rabbits, beaver, rats, feral cats and dogs, and had I been in the mood to eat them all, most would have had very little meat damage done to them, the fur bearer shot with the single 00 pellet have a almost invisible entry wound when the hides are washed out. The vermin died very fast, and second shots are as fast as you can thumb back the hammer.
Target shooting, it may not be world class for punching paper, but if your talking plinking fun, its a serious giggle to shoot.
carrying, its light as a feather, carries like its not there till you need it, and holsters galore exist for it.....
Shooting 85 grains of lead and 5 grains of trail boss you can shoot all day and not make a dent in 10 dollar bill, doing the say with the big cannons, ten bucks is here and gone about 10 shots in...