I have heard such good things about +P 158 gr. LSWHP's! Which makes it all the more frustrating that none of the gun shops near me stock them! Who currently manufactures such a load, anyway?
No matter how good a load I were able to formulate myself, I would never even consider carrying handloads for defensive purposes. I would not want my gun's ammunition to be an ant-gun prosecutor's ammunition.
I, too, made the switch from Speer's +P 125 gr. GDHP's to their newer 135 gr. loading. I never quite got comfy relying on such a light subsonic projectile. After looking at a couple of reviews, the 135 does, indeed, show a great deal of promise.
If you are a velocity fiend, don't overlook the ultralight exotic frangibles such as Glaser's Safety Slug. It is only a 95 gr. bullet, but out of a 2 inch barrel you're getting about 1200 fps.(!) And terminal ballistics are devastating. Also, bullets of this type do not penetrate most buildng materials and usually do not ricochet. If you live in an apartment building with thin walls, or expect to employ the arm in a tightly populated urban environment, this could be a good thing for neighbors and bystanders if you miss the assailant. But, then, you would never miss, would you?
By the way, I am brand spankin' new to TheFiringLine, and am lovin' it!