I've considered the .44spl on and off for years.
It is a relatively powerful load, with a nice big bullet, with very little recoil. There are a ton of great revolvers made for it from big old classics, to terrific carry guns. What's not to like?
The main reason I don't have one is that I'm not really looking to add a new caliber right now. I sold my .41mag, partially to consolidate, and definitely to limit my expensive (and somewhat hard to find) calibers. I have 9mm, . 380, .40 and .45 in autos, and .38spl, .357mag and .45LC in revolvers. Still, the Taurus 445 (especially in the current 22oz aluminum version), the Taurus 431, the Rossi 720, and the S&W 396 are perpetually calling to me and it is probably only a matter of time. Some of those N-frame S&W's look pretty nice as well (I've liked all the Thunder Ranch revolvers, maybe I should break down and look for a 21).