I have the Henry Big Boy in .both 44 and .357 mag.
Both shot very accurately right out of the box with factory sights. I am a woman and have no problem with the weight. In fact, my favorite activity with these after I have played with a paper target for a bit is to throw out one of those orange rubber balls or blocks and chase it down the range as fast as I can. The smooth action makes it easy.
The weight makes the swing and reacquisition of the target really easy. I do let the bone in my forearm do the holding, though, by keeping my off hand close to the lever and my elbow close in. I have taught this technique to several women who have had trouble with rifles and it made a difference in their ability to shoot them. Also works for kids.
I don't mind the tubular magazine at all. Different rifle, different design. If you like the side loader, get the Winchester or the Marlin. The heavy barrel doesn't heat up much, so holding the barrel for reloading isn't usually a problem until you have shot more than 50 rounds in very close succession. I did have to trim the O-ring a bit though, it was hard to rotate the tube at first, but that may just be me.
Beauty is in the eye of the beholder. I happen to think the Henry is very sharp And whenever I take one to the range, heads turn and people comment on it. No one who has shot one of mine gives it back with less than a big grin.