Of course any cartridge and any pistol can be used for self defense if necessary, but I think I would prefer something other than a heavy target pistol with sharp edges and powder-puff wadcutter loads. I also would probably be able to hit better with a Model 52 than with my Model 19, but under stress, and with even the possibility of the prospective target being something or someone I DON'T want to shoot, I would like a trigger pull a bit heavier than the one on my Model 52.
Jim
Jim