I have been shooting SA revolvers off and on for almost 30 years,mostly Rugers, some Colt copies. I carry a Vaquero, 4 5/8" barrel in an ISP holster. It's a convertable, .45 ACP/ .45Long Colt. I usually carry 230grain JHP .45ACP in it, sometimes CCI Blazer 200gr JHP in Long Colt. I practice with the same ammo I carry.
I practice more with this revolver than I do with my DA .357's because I enjoy shooting it more. I carry it often and I do carry 12 extra rounds in a small ziplock bag in a pocket, even though I'd have to be in a war to be forced to re load this gun under fire.
Speaking of war, I knew a guy who carried a SA revolver through a tour in Vietnam as an unauthorized "personal weapon." I don't think he ever used it, but it was always there and I know from personal experience that it survived the trip in good working condition.
I like SA's because they are as close to 100% reliable as it's possible for a machine to get, and Rugers even more so.
Deliberate, aimed, accurate, powerful fire is the key, IMHO. A SA revolver will do this quite well with practice on your part.They are also great fun.
Mark