Some years ago, one of the gun rags did an article on this subject.
For starters, they borrowed a nickle-plated Firest Generation SAA from Jock Mahoney, the TV and movie actor who played Tarzan and Yancey Derringer. Then they had to cast the bullets. That was a pain in the butt because silver requires nearly 2000 degrees to melt. Then they shrunk smaller than bore size.
Accuracy varied from mediocre to crummy. On top of that, the reloads caused the plating to start peeling off the revolver.
In earlier, more superstitious times, it was not uncommon for people to actually keep silver or gold bullets to dispatch supernatural critters or people allegedly in league with the Devil.
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