I use the 110 grain 270 in my 6.8SPCs now and then, but they always shed their jackets on deer and antelope. 100% of the time. So far I have shot 4 deer and 5 antelope with them.
If the construction was the same with only the weight being different, I would not be encouraged.
I have killed a lot more game with the 100 grain Remington from my 6.8s which is not as accurate, (1.2 MOA from the Remingtons and .6 MOA from the Sierras) but in all cases but one, the Remingtons have given me exits and I have not seen one blow up from my 6.8s on any deer, antelope or domestic sheep yet.
I get 2812 FPS average from my rifle and 2620 from my carbine and I have shot deer and antelope from as close as 70 yards and as far as 275.
In my 270 Winchesters and my 270 Short mag I have gone to tougher bullets. But keep in mind that I hunt elk with my 270s as well as deer and antelope, so I require more penetration then you would on deer alone.
I do not doubt the Sierra Pro-Hunters will kill the deer, but I personally believe there are many better choices.
The explosive effect of a 270 in the chest of most game drops them like lightning, but if you need to break big bone and you want exits every time, I would go with something tougher. Tougher bullets kill nearly as fast when they don't break into "metal sand", and you can still get 100% penetration from the tougher bullets so I don't see any extra virtue from bullets that blow up.
My old 270 Short mag loved 160 grain Nosler Partitions and I killed deer antelope and elk with it. I just could not fall completely in love with the rifle so I sold it (A Benelli R1 Auto) but I didn't have a single thing to complain about. It shot close to MOA and would kill game as well as you could ask for. The longest shot I ever made on an elk I made with that rifle and load.
As a side note, one 270 Pro-Hunter that I killed deer with years ago that worked VERY well was the 150 grain Round Nose, but Sierra doesn't make them anymore. I also saw good results from their 220 grain round nose in the 30-06 and 300 Win Mag.
So I have to say all Sierras are not "explosive" but the 270s spitzers in 110, 130 and 150 have all broken up when I have tried them in the past In 270 Winchester. I used some in the late 60s and the early 70s, but I gave up on them for hunting deer back then.
Today I like Noslers Partitions and Accubonds, Barnes TMX, Hornady Inner-Bonds, and I also have had excellent results from good old fashioned Winchester Power Points.