It will all depend on the noise I hear that wakes me up. The furcritter in my house is a kibble-fed, gas-operated 12 pound feline predator and if she's not reacting to it I'll consider it a low probability event. But if she's poised to move fast I'll know something is up.
Like another post, I have strategic night lights around the house. Not so much for intruders but to avoid stepping on felines (I used to have 3 including a 19 lb male tom cat studying to be a lion).
Immediate threat reaction is a 2.5" S&W M66 with a pair of .38 special +P 125gr JHP. Those are followed by 4 .357 Mag 125gr JSPs. If I hear movement outside, the 1911 slide gets pulled back in preparation to launch 230gr Hydrashoks.
When I wasn't single, a Winchester 1200 pump was slung under the bed and would launch #6, #4, #4, 00, 00, slug.
I also keep dark blue sweats in reach in case I have time to don them. Also nearby are the Surefire 6P flashlight, a maglite and a Gerber MK II blade.
I'd like to find a good, inexpensive (under $550) M1-Carbine as a short rifle.