If I were presented with that mulie at that angle, I would take him in the neck, straight above the yellow #3 arrow, even with the bottom of his mouth. That will sever the spine. Notice how the spine of the deer curves in the diagrams.
1, 2, or 3 will likely kill him but will bust the shoulder and could get into the paunch and make a stinking mess. I would rather not clean $hi! out of the inside.