Sgjr, . . . there are a lot of factors which will determine your shot placement. One of which is the weapon you carry. If it is a .357, 9mm, .44, or .45, . . . or similar (or greater)power, . . . then COM shots are where you should start.
There are many definitions of COM, . . . but basically it is intended to be a heart/lung shot right through the middle of the chest cavity, . . . from what ever angle you shoot it.
OTOH, . . . if you carry a mouse gun (.380 or lower) you may want to hone up on your shooting and plan for a face/head shot.
Plenty of folks met their demise from a mouse gun to the face, . . . and I really haven't met one yet that I would be willing to put even money on his/her surviving 8 or 10 LRHP .22's from less than 20 feet, . . . focused on the center of their head, . . . regardless of the angle.
Remember, . . . shooting another human in a civilian situation is limited to self defense, . . . so you don't shoot to kill, . . . you shoot to stop the activity the bg is involved in that causes you to fear for your life.
Hope this helps.
May God bless,
Dwight