Well, I've probably shot more game with Sierra bullets than anything else. Mostly in .270 Win., .308 Win. and 30-06. Deer shot and deer died. The last animal I shot with a Sierra bullet was an antelope in New Mexico, the bullet then 150 gr. Game King. The shot was at roughly 75 yards and the bullet hit in the short ribs on the left side and exited close behind the right shoulder. The antelope did about a thirty foot half circle and expired. Meat damage was very little with most of the loss in rib meat. However, most game I've taken has been with the Sierra Pro-hunters and results were good.
I personally have never shot any big game animal with the .243 but have seen a couple taken by friend which were literally bangflop/DRTs. My .243 back then was a cheap Kodiak Mauser that was quite accurate with 100 gr. Hornady spire points so that what I shot in that rifle. During the years 1977 and 1979 I took several of the neighbor kids out for their first deer hunts. I had a deal with a rancher who allowed me to take the kids there for their hunts. I'd let them shoot the rifle over a period of several weeks prior to the hunt so they'd be comfortable with the rifle and then take them to the ranch. During the two year period six kids took their deer off the ranch with that .243.
Interesting as one deer was a bang flop/DRT, four ran various distances from a few feet to as far as fifty or so yards. One deer however ran about 250 yards hitting the fence at the end of the field. He backed up and hit it twice more before finally falling down and expiring. On autopsy, the lungs and heart were just a mess with severe damage to all three organs. To this day I have no idea how or what let that deer take off and run that way. BTW, these were all fairly large Nevada Mule Deer.
PB