I have all kinds of handguns and feel confortable and confident with either, up to a point. Semi-autos are usually easier for me to conceal on my person, So when I want a resonably powerful weapon for CCW, I usually choose a lightweight commander type 1911, but in my car I might have a Glock model 22 in 40 cal.
At home on my headboard and nightstand will lay both a 5 inch series 70 Colt 1911, and a Smith and Wesson N-Frame in 45 ACP with a few extra full moon clips.
But if my clothing choices dictate, I might be carrying a little 5 shot J-frame 38 or even a Colt Pocketlite in .380 possibly with a Ruger LCR for backup, other times it might be a Kimber 3.5 inch 1911.
And sometimes it might be a singleaction 45 colt, and frankly if the chips were to fall, I would probably rather have that 45 colt singleaction then all of my smaller guns, until I get to the bigger semi-autos.
But if I am out of doors, I usually prefer a 4 inch Model 29 revolver in 44 mag.
So, as you can see, it just depends, I know the advantages and weeknesses of all of them, and none are perfect, but some are more perfect then others, based on a blend of power, and concealibility needed at the time. Sometimes a .380 in your pocket is better then a Glock 22 back at home, I can shoot them all pretty good, but sometimes I can only carry a little gun, but I feel better carrying a big when I can, even if it's a singleaction peacemaker.