There are some pretty strange responses in this thread.
I'm going to just go ahead and rip off Wyatt Earp and change one of his quotes a little bit. He said; "Speed is fine, but accuracy is final." Well, I'll add to that; "Power is fine, but accuracy is final."
As long at the power is there to get deep enough to hit vitals...I'll take the accuracy. I will especially take that accuracy if the reduction in recoil and flash is enough to allow for a faster accurate follow up shot, specifically in a self defense scenario. I'm not a big proponent of one-shot stops, but have noticed when reading statistical studies that two bullets almost always get the job done. I just want to stop the threat as quickly as possible.
I would even take a smaller hole which goes where I want it over a bigger hole that might be off a few inches and miss what would have been a heart or spine hit. CNS disruption or blood loss are all we can count on to end the threat more quickly.
Heck, I'll go one further...two holes per bullet are better than one, as long as there isn't enough energy to put a third hole in a second person. I'll take two holes leaking blood over one hole.