I assume you are talking about 5 shot 38 / 357 revolvers??
If you want the lightest gun out there S+W airwight is the way to go, if you want a relitivly trim steel gun S+W is again the way to go. The quality of the S+W guns is good and they are widley used and carried by many, however the new ones do have the internal lock if that matters to you.
If you want the most rugged and one that you can shoot 180 hard cast out of with out extream punishment (i.e. you could carry it in the back woods with medium sized hunting loads for protection) get the Ruger SP101, I have done this and while the kick is stout it's not crazy or impossible to manage and the gun is on the chunky side in the weight department so that helps. Rugers have no lock and tend to run cheaper than equivilent S+W products.
If you are going to move up to a 6 shot S+W has a mutitude of offerings with either fixed or adjustable sights, again all with the internal lock and all quite good in general, Ruger has the GP100 that comes in 3 inch with fixed sights and 4 inch with adjustable, neither with a lock and at a somewhat lower price than the Smith. If you plan to carry more than a 357, it is possible as many folks cary a 45 acp revolver or 44 mag --- both N frame guns however it's not something everyone is comfortable with.
So far as Tarus when we are talking about defensive revolvers none of the commonly carried rugers or S+W guns are so expensive that I personally think it's worth looking at Tarus, you will find devoted Tarus shooters here who will push the brand hard, however you will also find many stories of failure, problems, broken guns, long waits for warranty service, poor customer service and so forth. In addition I have personally seen a tarus with 1/3 of it's top strap eaten away due to some kind of defect in the metal. While any brand can put out a problem gun, Tarus seems to do this much more frequently and for that reason I stay away from them.