Not considering .45 Auto Rim ....
I sold my 625 3-inch as I didn't like the balance compared to the 624 3-inch.
But I can understand why some would like to carry the 625. I had some Ahrends boot-style grips for it and after sanding down the finger groove a bit, I thought those grips made for a compromise in size and feel. And yeah I'll kick myself someday for selling the gun although I still have the Ahrends grips.
And yes, the .45 ACP rounds will headspace in the cylinder just fine and will fire, all without any type of clip. The clips are for ejecting and moments later, faster reloading.
So if you like the Speed-Strip type (which is registered Bianchi trademark and only in .38 / .357) you can get a certain Quick-Strip from Tuff Products. The model number is 641 and the site says:
6 ROUND .243/.257 ROBERTS/.270/.308 .30-06/.338 FEDERAL/.41 MAGNUM/.45ACP
So you carry the gun loaded with a clip, and for a speedy reload you could have ONE Quick Strip (above) with 6 more .45 ACP rounds. After that, your emergency had better be over since your next reload will be slow.
The half-moon clips are a fine idea and not too hard to carry in a slim-ish reload pouch. This one might work:
Pouch from Tuff Products
Bart Noir