Welcome to TFL!
I have a question for you, when you say "Vaquero", what gun are you talking about, specifically?
There are two different guns people refer to as "Vaquero", in casual conversation. And they are NOT the same gun.
The stainless gun is a
Vaquero in .45 Colt, with a 4 5/8" barrel.
The blued gun is a
New Vaquero in .45 Colt with a 5 1/2" barrel.
Note how they are almost exactly the same over all size.
The VAQUERO is essentially a new model (post 1973) Blackhawk with fixed sights. It was made with the large (44) size frame. They are bigger, beefier guns than the Colt SAA. After several years, Ruger dropped it from production, replacing it with the NEW VAQUERO.
The New Vaquero (the guns say "New Vaquero" on them), is built on a smaller frame. The NEW VAQUERO is the same size as the Colt SAA (and clones).
The Vaquero can handle "Ruger only" loads in .45 Colt. The New Vaquero cannot. (if that's your thing)
I don't know what was going through the heads of the boys in the marketing dept when they gave their new gun the name "New Vaquero", but the unintended consequence is that people say just "vaquero", and other than from context, we just don't know what gun they are talking about.
Since you are comparing the Ruger to the Uberti, I assume you are talking about the New Vaquero, but I can't know, unless you tell me.
Between the Uberti and the New Vaquero, I would choose the Ruger, but only because I have decades of experience with the Ruger (new model) operating system. There is no half cock. opening the loading gate frees the cylinder for loading and unloading. And the transfer bar means you can carry 6 in safety.
The Colt is different. The Uberti is the same as the Colt (I think the even the ones with transfer bars still have half cock, etc.)
The Ruger uses coil springs. Colts (and clones) have flat mainsprings. And Ruger is an American company (if that matters to you).
So, which Vaquero are you actually looking at?