I have no experience with 10mm magnum but for someone looking for something more in 10mm, it would seem like a likely avenue. I do have revolvers in 10mm and 41 mag, two 6.5" Ruger 10mms and a Ruger 5.5" Redhawk in 41 mag. I have never bought factory rounds for the 41 mag and the 10mm factory stuff I bought is pretty tame. Handloading your own ammunition the 41 mag has the edge in power but it is not a big jump from the 10mms. Both 10mms are very accurate (as is the 41 mag) and this is a round that headspaces on the case mouth, not on the rim like a 38/357 mag. I would think that just hanging a 10mm unsupported at the mouth in a 10mm mag chamber would not make it shoot better. The moon clips are not as solid as a case rim. It may work fine and if the 10mms did not shoot very well this may have been something worth looking into.