My second shot at this thread: In addition to the two Mark iii's, a Target and a Competition Target, I have a Mark ii, Government Target. The Mark iii Target has a shorter barrel than the other two, but is just as accurate.
I shoot both Mark iii's using scopes, at rest; they are crazy accurate at 25 yards. The Mark iii Competition Target and the Mark ii Government Target have longer barrels giving better sight relief. The Mark iii's are drilled and tapped from Ruger, allowing use of a rail and red dot or telescopic sights with any further work. The Mark iii's have the loaded chamber indicator (LCI) and a mechanism that requires a mag inserted to fire. Some folks have had problems with the LCI; they're easy to replace. The mag firing mechanism is easy to remove, which lightens the trigger pull, but makes things loose unless one installs a spacer, or a different hammer bushing. I've modified my Mark iii's with Volquartsen hammer and trigger parts and after market hammer bushings. The Mark ii is nice and smooth in stock condition, but can be improved with specialty parts. My eyes are old and tired, so I wish the Mark ii was drilled and tapped so I could use a red dot, or scope on it.
Alloy and plastic pistols frames have never been a problem for me. I own 10 HK's (most of which are plastic frames) and several pistols with alloy frames. Internal, action parts is another story. And, the bolt stop on the alloy frame Buckmark can be an issue for a high volume shooter.
I've tried the new S&W Victory. It's a sweet little plinker, heavy, but smooth trigger. Might be more accurate with a Volquartsen barrel available thru S&W.
My favorite .22lr pistol is the S&W Model 41; it's still available without being declared "rare", scarce and way, way over priced as some older, excellent pistols are. I owned a S&W very similar to Model 41; it was really accurate, can't remember it's model. The Hammerli Xesse Sport is a fine .22lr. I have several .22lr conversion setups, including a SIG p210 and a HK4 with a .22lr barrel. For everyday shooting of whatever ammo is available I still recommend the Mark iii's. They're relatively inexpensive, accurate, reliable and readily available.