GP100 v S&W 686 Endurance Testing
In response to laytonj1's post: "Since no one has taken numerous samples of both and fired 10's of thousands of rounds thru them under controlled conditions to test for a durability advantage, any answer you get will be an opinion."
In my agency (a major federal law enforcement agency) we conducted endurance testing on both of these revolvers. This was done during bid evaluation processes for subsequent award for agency issue sidearm. A part of the endurance test included 10,000 rounds of 158gr .357 Magnum with careful round count tracking and malfunction/failure documentation against the contract standards. I was blessed with the opportunity to prepare two of these types of contracts and lead the T&E. Ruger and S&W submitted multiple samples of each of these models for the tests.
Simply, the results consistently and overwhelmingly favored the Ruger. At that time Steve Vogel was VP at the Prescott Plant and we discussed the reasoning. (Steve passed away far too young; outlived by his father-in-law, Bill Ruger) According to Steve, and borne out by many experienced firearms instructors of the day, the Ruger metallurgical formula and investment casting processes created a stronger stainless steel than either S&W and Colt (Colt was not part of our testing). This claim was also borne out by our Armorers, who worked extensively on both S&W and Ruger revolvers. Consistently, across the federal law enforcement agencies of the day, carrying revolvers, the Rugers held up better than S&Ws. It's important also remember that the S&W L Frame came into being in response to failures of the K Frame to handle steady diet of high pressure .357 Magnum (high when compared with the venerable .38 Special).
OBTW, both S&W and Ruger samples in both sets of endurance tests held up far better than the instructors and some volunteered students who had to fire the 10,000 rounds through each sample!
So, the Ruger GP100 won the overall contract and the field agents revolted. Both the GP100 and the L Frame are (were) too large for comfortable, concealed carry on a daily basis. Ruger created the GP100 to compete with the S&W L Frame and to carry Bill Ruger's vision of modular-ization and modernization of the firearms manufacturing processes to a new level. The GP100 family replaced the Security Six/Speed Six family - which was also proven far more durable than either the S&W K or L Frames. The GP100 was another one of those engineering solutions to a non-existent problem.
For target practice, home defense, field carry, hunting, and endurance testing, the GP100 is an excellent choice. Comfortable, concealed carry of either the GP100 or the S&W L Frame family (including 686) is best left to those of quite large builds wearing a heavy belt. For that application, in a wheelgun, Ruger's SP101 family is a more practical option; same metallurgical and investment casting durability in a smaller package with, regrettably, one fewer cartridge in the cylinder.
I hope this contributes to the discussion in answering some of the questions on endurance comparisons. Stay safe.