killed one with a 300 win mag. Shot it right where the neck met the body @ about 50 yds. while deer hunting. I have shot them in the head with my 22-250. But, If I were to use a rifle for turkey hunting, I'd have to go with 22 win mag, or a 17 cal. The 17's are really made for accuracy. A 22 won't mess up meat like the centerfires will if you hit a body shot. A turkey shot in the body with most centerfire rifles will pretty much all but destroy it. An extra full brenneke turkey choke is really the best option in a 12 ga. though. I like #5 shot.