The Ruger Predator is a good rifle for the money. I've been very impressed with the reported accuracy.
I liked the .22-250 Rem for varmint hunting, but had a few concerns. First, the twist on my Remington 700s was too slow, so it wouldn't stabilize 60 grain bullets. Second, it is pretty wind-sensitive beyond 200 yards, especially with 50-53 grain bullets. Third, it's not a great cartridge to reload for, due to the tapered case walls that cause more case-stretching than other straighter-walled cases exhibit. Fourth, it's hard to spot misses with those small bullets, especially after using a .30-06 for varmint hunting, when younger.
I got rid of mine and got a 6mm Rem heavy-barreled 700 Varmint. It was much better, but too heavy to carry all day. You may want to look into the .243 Win as a better long-range varmint cartridge. Mine are very accurate and I like the extra power and wind-bucking 6mm bullets deliver.
Right now, Natchez and other mail-order companies are selling Leupold VX2s 3-9x scopes under $280. A great scope at a good price, but they're being slowly phased out. I have about six and won't buy anything else. JP