I never have figured out....
How the .357 can be the bees knees for stopping a 150-200lb man, but only marginal, or not enough for a 150lb (and for a lot of the country, that's a real big one) deer!
Seems like a strange double standard to me. Of course, with people, we aren't concerned with clean kill, only stopping an attack. If they die as a result of being stopped, oh well. And we are looking to kill the deer.
Still, it always seemed to me that if it can be counted on for one, it ought to work for the other. This does not mean I endorse the 5.56mm for deer, because the govt says its good for shooting people (the enemy), that's a whole different argument, and one for another thread. There is however, one similarity, our govt is not interested in making humane kills on the enemy, only stopping them.
Bullet selection is important for best results, and for deer the light bullets (125 and under) are not usually good performers, as they are optimised for humans, and how often do you need to take a quartering shot on a bad guy? I personally see no need for the heaviest (180s), but do not deny that they will work well, when extra penetration is needed.
If you use the 125, pick your shots carefully, and avoid raking shots and the heavy bones, for best bullet performance. 140-160gr bullets of proper construction have the mass and hold together to get through when the angle is less than optimal. 180s will do it too, and then some.
One word of caution, if you keep 125s for defense, and are sighted for them, don't just drop 180s in the cylinder and go hunting. Do some practice first, as they will shoot to a different point of impact. That's why your hunting gun should have adjustable sights!