I'd have to go for a shotgun.
Only one I ever took out with a pistol required a dozen shots (9mm LRN) head/upper body before it gave up the fight. Dog had it cornered nose to nose and wouldn't call off. Although it was only a medium sized coon I didn't care to risk getting close enough to pull the dog off and risk be attacked myself. Only an instant to stop them from tangling. I managed to save the dog from any injury.
Only one I ever took out with a pistol required a dozen shots (9mm LRN) head/upper body before it gave up the fight. Dog had it cornered nose to nose and wouldn't call off. Although it was only a medium sized coon I didn't care to risk getting close enough to pull the dog off and risk be attacked myself. Only an instant to stop them from tangling. I managed to save the dog from any injury.