In my opinion, micro guns, like .380 pocket pistols on down, are expert's guns. Meaning, you have to train a lot to be decent with any speed or distance involved. All the .380 pocket pistols I've fired are snappy, have difficult triggers, and usually poor sights (though not always). The most challenging gun that I've ever fired that was fully-functional was a .25 ACP FN Baby Browning. Firing quickly, I almost completely missed a piece of typing paper at 7 yards (a few shots hit). Firing deliberately and consciously, I could hit the typing paper with a full magazine, but it took effort for me.
I'd like to own one someday, if for just the challenge of shooting it, and with enough practice, I'd probably carry one occasionally. Also, a disadvantage in my opinion, .380, .32, and .25 are less available and more expensive than .45 ACP, 9mm, and .40 S&W. An XDS in .45 ACP is more controllable and easier to shoot than a .380 or .25 in their smallest lightest forms. Even a G43 or Kahr P9 is an easier gun to shoot. Heck, a PM9 is almost easier to shoot.
I didn't have issue with a Walther PPK, but they are as heavy as an XDS or heavier than a G43, Kahr's PM9 or P9. Walther's are awesome, but they have safeties, and so far, I own no centerfire handgun with a safety, so I probably should keep it that way. If I was a safety-guy, I'd probably strongly consider a PPK.