When I started in this hobby in 2008 there was a shortage in primers going on. The only primers I could get were large pistol magnum. I worked up my loads with them. Shot 1k of them without problem. Afterward I got some regular large pistol primers. I started low, and worked my way back up. The loads were the same. I still worked up to be safe. They all shot jacketed and lead .45 ACP just fine in my M&P full sized.
If they were all I could get today. I would not hesitate to use them. Just load a few lower, and test them while working up.