I have been shooting an old 1970s 45 Colt Uberti Cattleman exclusively at 20,000 psi 1220 fps 250 gr with 4.75" barrel for years. It has ~ .045" thick chamber walls between chambers.
I think it is getting some rotational slop. Not as bad as a new Ruger, but it is changing. And I am changing... getting too old for the 44 magnum like recoil.
The Ruger Blackhawk has .060" between chambers and gets published loads of 32 kpsi.
Those revolvers are loose when they are new.
The S&W 25 has chamber walls .066" and gets published loads of 41kpsi.
Those revolver shoot loose with wimpy loads.
What does it all mean?
There are more than one failure mode.
From hot loads the two I see most are split cylinders and shooting loose.
The cylinder splits are all pressure driven, and somewhat predictable.
The shooting loose is a crap shoot. I cannot predict when a revolver will get rotational looseness.