Just a follow-up to my original post.
The S&B SR primers which failed to ignite my .454 Casull loads with H110/W296 have no problem lighting off my standard .223 Rem loads using H335 and BL-C(2) powder. I've shot about 300 rounds with the SR primer through my ARs with no misfires yet. And for that I'm happy, as the primers are serving their intended purpose.
I also experimented with using the same S&B SR primers in my .357 Magnum loads using H110/W296 and experienced no problems with ignition. Surprisingly, the reduced power hammer spring in my Ruger GP100 was able ignite the primers with 100% reliability. Thus far, I've only fired about 50 of these rounds with the SR primer, but I consider it a bonus.
I have since also purchased several bricks of S&B SP primers and found them to be just as reliable as the other "mainstream" SP primers in the various pistol calibers that I reload, although they do take just a wee bit more effort to seat into the primer pocket. I did end up crushing a few while trying to seat them into S&B brass (9mm and .40 S&W) which is known to have tight primer pockets. That begs the question: assuming S&B use their own primers in their factory cartridges, how do they avoid crushing the primers during the seating stage???