As far as the carry options go:
In the past decade of almost daily carrying, I've had and routinely CCW'd the following wheelguns:
S&W M-10 (2")
Colt Detective Special (2", 3")
Colt Agent (2")
S&W M-60(2")
Taurus 605(2")
S&W M-64 (4")
S&W M-19/66(2 1/2", 3".4")
Taurus 627 Tracker (4")
NAA Mini (1", 2")
Taurus 66(3",4")
Tauurs 85(2",3")
The only revolvers that lend themselves to easy pocket carry are the NAA Minis and their larger J-frame/D-frame cousins. I prefer the Colt D-frames for the benefit of the sixth shot in the cylinder. Obviously, the airweights and scandiums shine in this arena, with the trade-off being increased recoil.
If you're going to go larger, then look to the 3" J-frames or better yet K-frames and their ilk. A solid gun belt, and either an OWB or IWB holster is necessary. You'll want to look for a holster that either puts the cylinder slightly above the beltline (a la Hoffners) to minimize bulk, or uses straps on the trigger area (think Chic Gaylord Constable IWB) or at extreme ends of the design (think of Sparks VM-2) to pull the gun close in to your body.
If you prefer blue guns, I'd recommend wearing an undershirt bewteen you and your weapon to minimize the contact with body salts. One of my Model 10s in blue got some damage to it before I figured out that little tip.
Another carry option is the Kramer Confidante shirt or Thunder Wear/Smart Carry. Both of the methods shine during the very hot summer weather and are unobstrusive, the trade-off being somewhat slower access to your weapon.
There is nothing wrong with carrying a 357 and loading it with 38s. I question my own skill during what my departed Grandmother would call "social unpleasantness" enough that I would not rely on a 22LR handgun to cease any hostile activity. If someone else has that level of confidence and/or competence then I applaud there nerves of steel, cracker-jack shot placement, and obvious years of training and exposure to such events that they are that good.