Hey Old Man,
I have the s&w 22 also. Excellent choice as many have noted. For my two cents, I think you are on the right track with the Glock. I have owned a sp101 357. It has the feel of a well built gun but it's no fun to shoot in 357 and I had a tough time shooting accurately with it. (as did gun mag reviewers) The Glock is fun to shoot, accurate, higher capacity and will have better resale if you decided to trade it.