Penetration the (almost) only meaningful measure for self defense ballistics?

How do you measure caliber effectiveness? Gotta use some 'standard' in terms of distance, materials, etc. Actual numbers don't mean as much as compared numbers. Again, using some sort of standard.

PLUS, tough to find people who will volunteer to be shot..maybe a standardized 'meat target', with thanks to Paul Harrell...:)
 
Even shooting millions of people wouldn't give any sort of definitive answer. There will be some clear, definitive better and not better rounds. In general, though, the studies would probably show no significance that would be considered a scientific certainty. Then there would have to be confirmed in another study.
 
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