WW 231 is, always has been, and likely always will be my go to powder, not only for .45 ACP but for just about every other handgun round I load.
I've gone through a lot of it since I started reloading in the early 1980s.
It's the only powder I've ever used in my .45 ACP rounds, and I see no reason to change.
I shoot a lot of lead, so no matter what powder I use it's going to be dirty from the lube and such. A good cleaning takes care of that.
There are only two cartridges that I load for which I do not use 231 -- .44 Special and .45 Long Colt.
In my .44 Special I use exclusively Trail Boss. It fills the case and gives tremendous accuracy.
In my .45 Long Colt I use Universal. It's a bit bulkier than 231 and allows me to easily duplicate original ballistics and take things a bit hotter if I want.