I'll respond to some of the "what ifs" regarding my sighting in of fixed sight revolvers. First of all, I have only a couple of fixed sight guns, and these see only casual use.
The question came up about switching ammunition/loads. My fixed sight revolvers are fed a pretty steady diet of one ammunition variety. And, over time, I've developed a number of loads that all perform nearly identical to each oher. This in case there is a shortage of preferred powder or bullet combinations. So even if I have to switch ammunition, it will still have the same point of impact.
Not at the same range I have sighted in for? (Pardon the poor English) I have sighted in to bring my shots on line, left or right, and dead on for elevation. Slight differences in range won't affect the impact enough to matter. This is usually no more than an inch above or below my aiming point, not enough to cause a miss.
But I don't expect pinpoint accuracy from fixed sighted guns. When it is critical, I go to a Super Blackhawk or Blackhawk. As I said, they are sighted to hit center of a 6" (appx) dia. circle at 25 yards using s 6:00 o'clock hold. So sighted, I've made head shots on ground hogs at ranges out to just over 100 yards.
Bob Wright
And.................I had an early Uberti Cattleman, ca. 1975, imported by Iver Johnson. To hit a gallon milk jug at some fifty feet or so, estimated, I had to aim at the big toe of my right (Wright?) foot. Not a very pleasant feeling with a .44 Magnum.