Thank you for that information.
I had several Vaqueros, a New Vaquero, and New Model Blackhawks in .45 Colt. Had my years of pushing the .45 Colt in the Blackhawk, decided not to bother with it after a while. I shoot the .45 Colt for fun (mostly) and a 250gr at 1100fps or just under (depending on barrel length) does everything I want and need from the round, and is safe in Colt class guns, as well. When I want more, I go to the .44 Mag or some other round in that class,
Ruger only level loads, while safe in the Vaquero (and NOT the NEW Vaquero) run into the problem of the fixed sights. With great power comes great responsibility, but without great accuracy, (meaning bullet hits where sights aim) its not a good thing.
I had a .44 Magnum Vaquero but traded it for a Super Blackhawk, to get "essentially" the same gun, with adjustable sights, which I felt was much better suited to shooting various .44 Magnum loads.