I wouldn't shoot much at all of any 110 grain Magnum loads.
Loads under about 135 grains are hard on revolver forcing cones and cause erosion or even cracking.
The police favorite performer was the 125 grain loads, which caused the S&W "K" frame forcing cone cracking problem.
The Python forcing cone is much thicker then the "K" frame but can still erode.
For a .38 Special, I'd go with Buffalo Bore's HOT +P 158 grain, semi-wadcutter, lead hollow point.
This is what the original +P was. Since then the ammo companies have been downloading the +P ammo until it's not much hotter then the older standard .38.
Buffalo Bore uses a special softer lead bullet with a gas check so they can drive the bullet at near Magnum velocities without excessive leading.
The cops called the early hotter +P the ".38 SPLAT" for the sound it supposedly made when it hit.
This +P load was what put an end to the old .38 Special round nose lead failures to stop.
As for a Python, check out the timing as I described in the gunsmithing section on Colt Fever.
http://www.coltfever.com/GUNSMITHING.html
You need to treat a Python nicely and not abuse it.
Abuse is slamming the cylinder shut with a Bogart flick of the wrist.
Don't cock it in single action by yanking the hammer back hard.
Don't shoot double action by jerking the trigger really hard.
The old Colt action is properly shot in DA by learning how to "roll" the trigger.
You can still shoot very fast without tearing the gun up.
For the extra care you get superb accuracy and the best single action trigger there was.
If you shoot it enough for the hand to wear or it develops cylinder end shake over 0.003" get it tuned up by Frank Glenn or Spartan Gunsmithing.
As for buying a Python, do the timing checks, check for excess cylinder end shake, and just LOOK at the gun.
Look for the usual rust or pitting, a re-blue job, or signs of abuse like dinked up screw slots.
Usually if a Python looks good, it IS good.
Watch out for Pythons "in the box" especially "New in the box". These days probably most are counterfeit boxes and end labels that you can buy on ebay.
Buy a good Python and treat it like you should and you're about as well armed as you can get.