I dislike recommending specific guns for somebody I don't know...
... because there are so many variables involved, from her build to her hand size to her athleticism to her mechanical aptitude to her general attitude.
You get the idea.
I very strongly suggest you and she both look at the Cornered Cat website I linked in post #16.
However, if you want examples of what women I personally know prefer>
My lady likes a 4" GP100 with .38+P best of any handgun she has shot, but she likes my AR better than any handgun, and my 870 better than the AR.
My ex liked my old Beretta 92 so much that we picked out a 92 Brigadier for her, many years ago. (She used that to defend against a pair of stalkers, once, and against some ATM robbers, on another occasion.)
My mother likes (and currently has use of) my SIG P239; she bought a Mosquito for less expensive practice.
My best friend's wife loves a Walther P22, and thinks she wants a Walther PK380 when she gets her permit.
A lady who worked at the gun shop I frequent carries a PM9 everywhere she goes.
In my circles, at least, the nod goes 4:1 in favor of autos. It also goes 3:2 in favor of compact over full-size. Note, though, that my lady doesn't carry - she keeps it in her nightstand. My ex carried the full-sized Beretta in a pocketbook holster - not my favorite mode, in case of purse-snatching, but better than nothing.
So, once again, you are much better off doing some more research, and then going to shops and letting your wife handle different types, shapes, and sizes.