You have to ask yourself what your intention is. If you plan on using the rifle to defend against or attack little fluffy bunnies and squirrels then the choice should be based on different criteria than if you are using it as a training tool for a higher power cartridge.
Personally, I think the threat of rabid bloodsucking bunnies is greatly underestimated by everyone but the British (watch the prophetic combat training masterpiece "the holy Grail" by tactical expert Monty Python). I like my stainless 10/22 in a folding stock with an extended magazine release and butler creek hi cap mags. I consider it my primary weapon against zombie bunnies, fanged squirrels, mutant tribbles and deranged rats.
If you are going to train with it as an alternative to a 5.56x45 weapon at an indoor range or to reduce ammo costs, then you need to choose one that has the same controls as your primary weapon.