You can think of it as a "home defense" rifle, but reality is that in a home defense situation, the only time you should use ANY rifle is if it is the only gun available at the time.
Inside the house, any handgun, even a pocket gun is easier to maneuver (doorways, etc) and outside the house, how do you justify shooting at ranges where a rifle is needed?
THe shotgun is very popular, although having the long gun's disadvantages inside the house, the lack of long range penetration is a benefit. Defensive shooting is a short range proposition. It is an extremely rare situation when it isn't.
Now, if the rifle is going to have another use (pest control, hunting, target shooting -formal or informal), and still be somewhat useful in a defensive situation, thats a bit different.
The Marlin lever guns (or Winchesters when you can find them) in a pistol caliber (.357mag, .44 mag, etc) are find handy guns, and while not as handy as a pistol inside the house, are much better than a bigger "hunting" rifle.
And they have the plus of NOT being a handgun, something that might be important depending on the laws where you are.
I gave my father in law a Marlin 1894 carbine in .357 one Christmas, for protection when he went camping. He wasn't a real gun person, but he loved the gift. Carried it in his camper for years on their trips. And he never had to worry about the laws in different states about handguns.